Pharmaceutical Organic Chemistry 2

Unit 1

Benzene and its derivatives

Analytical, synthetic and other evidences in the derivation of structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s rule

Reactions of benzene - nitration, sulphonation, halogenation reactivity, Friedel crafts alkylation- reactivity, limitations, Friedel crafts acylation.

Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction

Structure and uses of DDT, Saccharin, BHC and Chloramine

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Phenol

phenol

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Unit 2

Phenol

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Phenol

phenol

Acidity of phenols, effect of substituents on acidity, qualitative tests, Structure and uses of phenol, cresols, resorcinol, naphthols

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Phenol

phenol

Aromatic Amines

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phenol

Phenol

Basicity of amines, effect of substituents on basicity, and synthetic uses of aryl diazonium salts

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Phenol

phenol

Aromatic Acids

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phenol

Phenol

Acidity, effect of substituents on acidity and important reactions of benzoic acid.

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phenol

Phenol

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Unit 3

Fats and Oils

• Fatty acids - reactions.
• Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils.
• Analytical constants - Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value - significance and principle involved in their determination.

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Unit 4

Polynuclear hydrocarbons:

• Synthesis, reactions
• Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivatives

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Unit 5

Cyclo alkanes

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phenol

Phenol

Stabilities - Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only

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